�Low levels of LDL cholesterol as well as high levels are associated with cancer in patients with type 2 diabetes, found a prospective cohort study promulgated in CMAJ.
Researchers from the Hong Kong Institute of Diabetes and Obesity, the Li Ka Shing Institute of Health Sciences and The Chinese University of Hong Kong conducted a field of study of 6107 Chinese patients with type 2 diabetes and set up a V-shaped risk relation between LDL cholesterol and cancer in patients non receiving lipid-lowering medication therapy.
"LDL cholesterol levels below 2.80 mmol/L and levels of at least 3.90 mmol/L were both associated with markedly elevated risk of cancer among patients wHO did non use statins," state Dr. Juliana Chan and coauthors.
The study excluded people on statins as statins obscured the association between LDL cholesterin and all-site cancer.
Increasing data suggests an association between type 2 diabetes and an elevated endangerment of cancer, including breast, colorectal, pancreatic and liver cancers. An elevated risk of exposure of genus Cancer in patients with humbled LDL was linked to cancers of digestive organs and peritoneum, genital and urinary organs, lymphatic and blood tissues as well as other areas. Patients with an LDL cholesterin level supra 3.80 mmol/L had heightened risks of oral, digestive, bone, skin, connection tissue, breast and other cancers.
Regarding clinical implications, the authors suggest "the use of these levels as risk markers may help clinicians to evaluate their patients more in full and therefore to forestall premature deaths in patients who have high peril."
They bid for re-analysis of data from clinical trials to confirm or refute these findings.
In a related commentary, Drs. Frank Hu and Eric Ding of Harvard School of Public Health order confounding factors such as indication for the use of statins, lifestyle and socioeconomic status must be considered when looking at the tie-up of high levels of LDL cholesterol and the risk of cancer.
"Low serum cholesterin is usually observed in individuals with ill health (e.g. cancer patients) and those with unhealthy lifestyle characteristics such as smoking and heavy imbibing," states Hu.
About CMAJ (Canadian Medical Association Journal)
CMAJ is the leading health sciences journal in Canada. CMAJ is a general aesculapian journal publishing original research and revue articles, commentaries and editorials, practice updates, an humanistic discipline and ideas section and health news. Published continuously since 1911, new issues are uploaded on hypertext transfer protocol://www.cmaj.ca every second Monday at 4:30 p.m. EST/EDT. http://www.cmaj.ca contains the complete editorial contents of CMAJ, supplemented by a variety of interactive features and extra content.
Canadian Medical Association Journal
More info
